Adrenal glands, also known as suprarenal glands produce a variety of hormones including adrenaline and the steroids aldosterone and cortisol that help regulate metabolism, immune system, blood pressure, response to stress and other essential functions. The adrenal cortex produces hormones that controls sex (androgens, estrogens), salt balance in the blood (aldosterone), and sugar balance (cortisol).

Adrenal fatigue is a term to describe adrenal gland insufficiency caused by chronic stress. Prolonged exposure to stress could drain the adrenal glands. Symptoms of low cortisol due to adrenal fatigue can be: fatigue and morning sluggishness, low mood (aka mild depression), anxiety, weakened immune system, low resilience to stressful situations, brain fog or mid-day lack of focus, cravings for salty or sweet foods.

The stress caused by hormone imbalance in perimenopause and menopause women, is a huge contributor to adrenal fatigue. During extremely challenging periods in a woman’s life, the stress response can take over and reduce the production of sex hormones. As a result, adrenal fatigue can worsen a woman’s menopause symptoms.

Adrenal fatigue in men occurs when a man’s stress levels remain elevated for a prolonged period of time. Prolonged, elevated stress can result in abnormal cortisol levels and, in turn, affect all the other hormones in the body. Like with women, adrenal fatigue can decrease sexual drive in men.

ADAPTOGENIX is a combination of carefully selected ingredients to address adrenal fatigue.

Skullcap (Scutellaria lateriflora) is a popular herb in traditional medicine systems and the western materia medica for anxiety and related disorders^{1, 2}.

Schisandra (Schisandra chinensis) is a famous traditional Chinese medicine to treat fatigue via aspartate and glutamate metabolism pathways³ and via fighting oxidative stress⁴.

California poppy (Eschscholzia californica) classified as a nervine herb is a non-addictive herbal remedy acting on the GABA receptors⁵. It has calming/anxiolytic properties⁶.

Ashwagandha (Withania somnifera)  an Ayurvedic herb classified as a Rasayana nervine tonic. It is an adaptogen, a substance that helps the body cope with stress ⁷.

Rhodiola (Rhodiola rosea) is an adaptogen with a long history of use in traditional medicine to treat stress-induced fatigue and depression, enhance physical performance and work productivity⁸. Its effect is enhanced when associated with Schisandra, as in this product⁹.

Adaptogenix composition

Ingredients / capsule:

Does not contain: dyes, preservatives or artificial sweeteners, dairy products, wheat, gluten, yeasts, soy, corn, eggs, nuts.

Recommended dose (adults): 2 capsules 3 times a day or as recommended by the specialist. Do not exceed recommended dose for daily consumption. Suitable for vegetarians and vegans.

Take with:

• NADH+ in case of severe mental fatigue (i.e. morning fog).

Warnings:

• Do not use if you are pregnant or breastfeeding.
• Do not use if you suffer from bipolar disorder. If you are taking anti-depressant medicines / hormone treatments / oral contraceptives, consult your specialist before use.
• Avoid taking with alcohol or products that cause drowsiness and/or pain relievers.
• Consult a health care practitioner if symptoms persist or worsen.
• Some people may experience drowsiness.
• Be careful if you operate heavy machinery, or drive, or if you participate in activities that require alertness.
• Discontinue use if you experience irritability or insomnia.
• Dietary supplements do not replace a varied and balanced diet and a healthy lifestyle.
• Keep out of the reach and sight of small children.
• Store at room temperature, in a dry place and away from heat sources.
• Sealed for your protection.
• Refuse product if cap seal is broken.

Adrenal fatigue due to mental and/or physical stress can induce a non-restful sleep?

Provita Nutrition and Health Inc., Port Coquitlam, BC V3C 1S2, CANADA;

1. Christine Brock et al. American skullcap (Scutellaria lateriflora): an ancient remedy for today’s anxiety? British Journal of Wellbeing, 1 (4). pp. 25-30, July 2010.
2. Christine Brock American skullcap (Scutellaria lateriflora L): a study of its effects on mood in healthy volunteers., Ph.D. thesis, University of Westminster, UK, 2012
3. Aiping Chi et al. Metabolic mechanism of a polysaccharide from Schisandra chinensis to relieve chronic fatigue syndrome, Int J Biol Macromol. 2016 Dec;93(Pt A):322-332
4. Shuai Shao et al. Antifatigue Activity of Glycoprotein from Schisandra chinensis Functions by Reducing Oxidative Stress, Hindawi – Evidence-Based Complementary and Alternative Medicine Volume 2020 | Article ID 4231340
5. Milan Fedurco et al. Modulatory Effects of Eschscholzia californica Alkaloids on Recombinant GABA_A Receptors, Biochemistry Research International Volume 2015, Article ID 617620
6. A Rolland et al. Behavioural effects of the American traditional plant Eschscholzia californica: sedative and anxiolytic properties, Planta Med. 1991 Jun;57(3):212-6
7. Adrian L. Lopresti et al. An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract, A randomized, double-blind, placebo-controlled study, Lopresti et al. Medicine (2019) 98:37
8. Emilija Ivanova Stojcheva and José Carlos Quintela, The Effectiveness of Rhodiola rosea L. Preparations in Alleviating Various Aspects of Life-Stress Symptoms and Stress-Induced Conditions—Encouraging Clinical Evidence, Molecules. 2022 Jun; 27(12): 3902
9. Alexander Panossian et al. The Adaptogens Rhodiola and Schizandra Modify the Response to Immobilization Stress in Rabbits by Suppressing the Increase of Phosphorylated Stress-activated Protein Kinase, Nitric Oxide and Cortisol, Drug Target Insights. 2007; 2: 39–54