Hepatothione – Pro Glutathione

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Named the “Super Molecule” or “The Mother of All Antioxidants” by Dr. Mark Hyman, glutathione is one of the most discussed topics in both the natural health and medical circles of today. Over 117,000 scientific articles have approached this molecule and experts now recognize that an alarming rate of people are deficient in glutathione.

The glutathione deficiency leads to:

  • increased oxidative stress;
  • decreased liver and cell capacity to detoxify;
  • accumulation of toxins and heavy metals in the body;
  • inability to repair DNA;
  • pro-carcinogenic cell mutations;
  • reduced amount of oxygen and nutrients in cells;
  • weakening of the cell membrane and eventual cell death;
  • speeding up the aging process.

These processes directly affect the state of the immune system and often become the main cause of the disease or its progression, severity and response (or rather, lack thereof) to treatments.

Glutathione plays a key role in strengthening both innate and adaptive immunity, and has profound effects on lymphocyte functions. All this adds up to an increase in our body’s capacity to fight both bacteria and viruses.

Low glutathione levels also mean that the prescribed medical treatments, instead of helping, may actually worsen the situation because synthetic drugs cause further declines in glutathione levels. For example, it has been scientifically proven that glutathione levels can predict how well and with what side effects cancer patients can tolerate chemotherapy and radiation.

Glutathione plays an important role in gallbladder health, helping the liver to detoxify fat before the bile is emitted, which reduces stress on the gallbladder.

Research has shown that almost all chronic conditions are characterized by the deficiency of glutathione: Alzheimer’s, Parkinson’s, asthma, all cancers, cataract, macular degeneration, glaucoma, chronic fatigue syndrome, diabetes, autoimmune disorders, kidneys, lungs, heart and digestive system, fibromyalgia, influenza and cold, peripheral neuropathy, hepatitis, multiple sclerosis, skin disorders, seizures, tumors, autism spectrum disorders and many more. Due to these unfavorable effects of glutathione deficiency, it has been called the “Super molecule”.

People who consider themselves healthy may also have low glutathione levels. The main reason for this is age first, because the production of glutathione in cells decreases naturally with an average rate of 10% per decade of life after the age of 20 years. Secondly, every day we are all exposed to environmental pollution, exhaust gases, viruses, nutrition that does not contain daily nutritious foods with 7-9 servings of recommended vegetables and organic fruit a day. Such a lifestyle eventually leads to a certain degree of glutathione deficiency.

Healthy people may not see immediate results after rising glutathione levels. However, they will notice the improvement in energy levels, mind clarity, sleep and improved mood and will notice fewer flu, colds or other bacterial or viral illnesses. This is because glutathione strengthens the immune system and has profound effects on lymphocyte functions, increasing both innate immunity and acquired immunity. In other words, it can act both as an antibiotic and as a vaccine. In addition, it provides protection against the appearance of pre-carcinogenic elements.

There are many glutathione supplements on the market including the “reduced” form. The problem is, however, that the systemic bioavailability of orally consumed glutathione is poor because the glutathione molecule that is a tripeptide needs a specific carrier down to the cell membrane that is either insufficient or completely absent from the system. Even administration of high doses of reduced glutathione, up to 3 grams per day, only leads to a very small amount that can reach the liver, be processed and passed on to the cells.

A more effective method of increasing the concentration of glutathione in the body is to provide glutathione amino acid precursors in the form of Cysteine, Glycine, Glutamic Acid and Glutamine. They are taken up by the liver where they are then processed into the Glutathione tripeptide. However, in cases where the liver is affected, it no longer has the ability to produce enough glutathione from these precursors. Therefore, Hepatothione supplement provides a complementary process to produce endogenous glutathione directly in the intestines by a molecular fermentation process using a rare probiotic bacteria species, Lactobacillus fermentum. It feeds on Casein and Concentrated Protein from non-pasteurized milk, producing endogenous glutathione which is then transferred to the liver and to the rest of the body via a carrier such as gelatinized chitosan. This form of glutathione is 100% compatible with any animal species including humans and becomes bio-available immediately.

Therefore, Hepatothine is the only product on the market that also provides endogenous glutathione (Endothione).


Each delayed release capsule contains the following ingredients:

L-Cysteine Hydrochloride 125 mg
Glycine Hydrochloride 125 mg
D-ribose-L-cysteine 125 mg
Milk Protein Concentrate (80% Protein) 100 mg
Calcium caseinate 75 mg
L-glutamine 50 mg
ZL-glutamic acid 50 mg
Chitosan (crustaceans) 25 mg
Silybum marianum extract (80% silymarin) 25 mg
Lactobacillus fermentum (200 billion cfu / g) 10 mg
Selenomethionine 0.5% (50 mcg Se / 91% DRI *) 10 mg
Zinc sulphate (5 mg Zn / 50% DRI *) 9.1 mg

*DRI – Nutritional Reference Value according to Regulation 1169/2011

It does not contain: eggs, artificial dyes and flavors, yeast, sweetener, nuts, wheat, soy, gluten.


Recommended way of use (only for adults): 2 capsules, once per day, taken a few hours before or after other supplements / medicines, preferably on an empty stomach.


  • In cases of severe liver disease can be associated synergistically with Provita Nutrition’s Liver Hepato-Protect product.
  • In cases of hepatitis B or C, can also associated with Konig Nutrition Laboratorium’s Artemisinin forte product.


  • Contraindicated for people with lactose intolerance or allergic to milk proteins or crustaceans.
  • Consult your doctor before using if you are pregnant or breast-feeding.
  • If an allergic reaction occurs, discontinue administration.
  • Dietary supplements do not replace a varied and balanced diet and a healthy lifestyle.


  • Pietro Ghezzi; Role of glutathione in immunity and inflammation in the lung; Int J Gen Med. 2011; 4: 105–113.
  • Hamilos DL, Zelarney P, Mascali JJ.; Lymphocyte proliferation in glutathione-depleted lymphocytes: direct relationship between glutathione availability and the proliferative response. Immunopharmacology. 1989 Nov-Dec;18(3):223-35.
  • Carlos Guerra et al.; Glutathione and Adaptive Immune Responses against Mycobacterium tuberculosis Infection in Healthy and HIV Infected Individuals; PLoS One. 2011; 6(12): e28378.
  • Witsky et al.; The Systemic Availability of Oral Glutathione; European Journal of Clinical Pharmacology; (1992) 43:667-669
  • Rajagopal V Sekhar et al.; Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation; Am J Clin Nutr 2011;94:847–53
  • Rajagopal V Sekhar et al.; Glutathione Synthesis Is Diminished in Patients With Uncontrolled Diabetes and Restored by Dietary Supplementation With Cysteine and Glycine; DIABETES CARE, VOLUME 34, NUMBER 1, JANUARY 2011
  • Kullisaara et al.; Complete Glutathione System in Probiotic Lactobacillus fermentum ME31; Applied Biochemistry and Microbiology, 2010, Vol. 46, No. 5, pp. 481–486
  • Peran L. et al.; Lactobacillus fermentum, a probiotic capable to release glutathione, prevents colonic inflammation in the TNBS model of rat colitis; Int J Colorectal Dis. 2006 Dec;21(8):737-46

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*The results may vary from person to person, it is not mandatory to get the promised results mentioned on the site, or those already obtained by the persons who submitted their testimonials.