What is Ptero Gene™?
There are many species of antioxidants. But not all antioxidants are created equal. Although pterostilbene is a phenol that is chemically related to resveratrol it differs from resveratrol by increased bioavailability and has its well-defined activity in the body. Pterostilbene is isolated from the stem heartwood of Pterocarpus marsupium while resveratrol is extracted from the root of Reynoutria japonica (synonyms Fallopia japonica and Polygonum cuspidatum). Although they are both antioxidants, resveratrol and pterostilbene complement each other by the outcomes of their specific antioxidant effects. The antioxidant effect of resveratrol provides for activation of calorie restriction mimetic and telomere maintenance factors with main outcomes being cardiovascular and anti-aging effects. Pterostilbene acts as an antioxidant by activating AMPK (AMP-activated protein kinase) that regulates energy metabolism and by activating Sirtuin 1. Obesity and aging diminish Sirtuin 1 (1, 2). Sirtuin 1 is NAD dependent, therefore increasing NAD+ levels can enhance the effect of pterostilbene. SIRT1 is one of the most important transcriptional factors that drives many cellular activities, like energy metabolism, cell survival, DNA stability, inflammation, and circadian rhythms (3). Quercetin is itself an antioxidant complementing resveratrol and pterostilbene. At the same time when quercetin and Medium Chain Triglycerides (MCT) are associated with resveratrol and pterostilbene, it increases their bioavailability. BioPerine® (Sabinsa Corp.) increases resveratrol delivery (4).
A large number of studies demonstrate that pterostilbene has diverse pharmacological activities for the prevention and treatment of diseases including inflammation, cancer, diabetes, dyslipidemia, inflammation. Pterostilbene improves the cellular stress, inflammation, and Alzheimer’s disease pathology through upregulation of PPAR-α expression (Peroxisome Proliferator-Activated Receptors regulating insulin sensitivity) showing higher modulator potential than resveratrol (5).
Who should take it?
To be used as part of an anti-aging protocol and for the maintenance of good health in particular by modulating energy metabolism and reducing fatty acids oxidation. By regulating energy metabolism helps burn fat and consequently gradually lose weight while improving insulin use (for diabetics) (6).
PTERO GENE (PTEROSTILBENE) composition
Ingredients / dose:
| Resveratrol (from 500mg Polygonum cuspidatum root, with 20% trans-resveratrol) |
100 mg |
| MCT / medium chain triglycerides (from 285,714 mg extract / maltodextrin from Coconut fruit potatoes / Cocos nucifera) |
200 mg |
| Pterostilben (from 111,112 mg wood of Pterocarpus marsupium, with 90% trans-pterostilben) |
100 mg |
| Quercetin dihydrate (from 41.052 mg hydroethanolic extract from Japanese acacia / Sophora japonica flower buds, with 95% quercetin) |
39 mg |
| Piperine (from 14,736 mg hydroethanolic extract from Piper nigrum fruits, with 95% piperine) |
14 mg |
| Charging agent: microcrystalline cellulose |
| Antioxidant: ascorbic palmitate |
| Capsule: hydroxypropylmethylcellulose |
Does not contain: eggs, gluten, wheat, corn, soy, ferments, nuts, sweeteners, flavors or artificial colors, or GMOs.
Net weight e = 35,238 g
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