FlavoNAC provides an orthomolecular combination of specific antioxidants targeting REDOX, REDOX signalling, mitochondria homeostasis and ROS control.

Our health starts with mitochondria health. Mitochondria are often referred to as the powerhouses of the cell. Mitochondria are known to generate approximately 90% of cellular reactive oxygen species (ROS). The imbalance between mitochondrial ROS production and removal due decreased antioxidants defense activity results in oxidative stress (OS), which leads to oxidative damage that affects cellular components such as lipids, DNA, and proteins¹ (Tirichen 2021). Redox is a process of oxidation-reduction, which are complimentary processes. Redox- dependent processes influence most cellular functions, such as differentiation, proliferation, and apoptosis. Therefore, Redox is important for the regulation of mitochondrial function^{2, 3, 4} (Handy 2012; Mailloux 2014), (Zuo 2022). Redox signalling is important for cardiovascular health⁵ (Madamanchi 2013)

Alpinia galanga (Greater Galangal) is an ayurvedic herb rich in phenolic compounds with antioxidant properties⁶ (Mahae, 2009)

NAC (N-Acetyl Cysteine) is an important antioxidant and a precursor for glutathione. NAC is also essential for reducing oxidative damage and mitochondrial dysregulation⁷ (Banaclocha 2022). NAC is also important for lung health affected by increased numbers of reactive oxygen species such as in the case of COPD (ROS)⁸ (Dekhuijzen 2006)

Hesperidin, an antioxidant flavonoid, attenuates altered Redox homeostasis⁹ (Kumar 2020). Important for lung health problems including lung fibrosis, asthma, chronic obstructive pulmonary disease (COPD), acute respiratory distress syndrome (ARDS), pulmonary fibrosis, emphysema, and other respiratory diseases¹⁰ (Hosawi 2023). Hesperidin functions as an ergogenic aid by increasing endothelial function,  inhibits ROS production, decreases production and plasma levels of pro-inflammatory markers¹¹ (Imperatrice 2022)

Quercetin is well researched bioactive flavonoid, known for its anti-inflammatory, antihypertensive, vasodilator effects, anti-obesity, anti-hypercholesterolemic and anti-atherosclerotic activities¹² (David 2016). Quercetin modulates intra-mitochondrial redox status and protects against mitochondrial damage¹³ (Oliviera 2015)

Did you know?  Alpinia galanga is a plant in the ginger family revered in Indian and Arabian medicine.

What does FlavoNAC™ contain?

Ingredients / vegetable capsule:

Net weight e = 47,028 g

Does not contain: eggs, gluten, milk, wheat, corn, soy, yeast, tree nuts, artificial sweeteners, flavors or colors, or GMOs.

Recommended way of use (only for adults): 2 capsules 1-2 times a day.

Warnings and precautions:

• Do not use it if you are pregnant or breastfeeding.
• Do not use it if you are taking antibiotics or nitroglycerin.
• If you are taking prescription medication, consult a health care practitioner prior to use.
• Stop taking it if you experience hypersensitivity (allergy).
• For use beyond 3 months consult a health care practitioner.
• Dietary supplements do not replace a varied and balanced diet and a healthy lifestyle.

Recommendation

• Useful association with Hesperine.

PROVITA NUTRITION & HEALTH Inc. CANADA

1. Hasna Tirichen et al. Mitochondrial Reactive Oxygen Species and Their Contribution in Chronic Kidney Disease Progression Through Oxidative Stress, Front. Physiol., Volume 12, 23 April 2021
2. Diane E. Handy and Joseph Loscalzo, Redox Regulation of Mitochondrial Function, Antioxidants & Redox Signaling, Volume16,Number11,2012
3. Ryan J. Mailloux et al, Redox regulation of mitochondrial function with emphasis on cysteine oxidation reactions, Redox Biology 2 (2014) p. 123-139
4. Jing Zuo et al., Redox signaling at the crossroads of human health and disease, MedComm (2020). 2022 Jun; 3(2): e127
5. Nageswara R. Madamanch and Marschall S. Runge, Redox signaling in cardiovascular health and disease, Free Radic Biol Med. 2013 August; 0: 473–501
6. Nopparat Mahae and Siree Chaiseri, Antioxidant Activities and Antioxidative Components in Extracts of Alpinia galanga, Kasetsart J. (Nat. Sci.) 43 : 358 – 369 (2009)
7. Marcos Martinez-Banaclocha, N-Acetyl-Cysteine: Modulating the Cysteine Redox Proteome in Neurodegenerative Diseases Antioxidants 2022, 11, 416
8. PNR Dekhuijzen and WJC van Beurden, The role for N-acetylcysteine in the management of COPD International Journal of COPD 2006:1(2) 99–106
9. Raushan Kumar et al. Hesperidin attenuates altered redox homeostasis in an experimental hyperlipidaemic model of rat, Clinical and Experimental Pharmacology and Physiology, Volume47, Issue4, April 2020 p. 571-582
10. Salman Hosawi, Current Update on Role of Hesperidin in Inflammatory Lung Diseases: Chemistry, Pharmacology, and Drug Delivery Approaches, Life 2023, 13, 937
11. Maria Imperatrice et al., Hesperidin Functions as an Ergogenic Aid by Increasing Endothelial Function and Decreasing Exercise-Induced Oxidative Stress and Inflammation, Thereby Contributing to Improved Exercise Performance, Nutrients. 2022 Jul; 14(14): 2955
12. Alexander Victor Anand David et al., Overviews of Biological Importance of Quercetin: A Bioactive Flavonoid, Pharmacogn Rev. 2016 Jul-Dec; 10(20): 84–89
13. Marcos Roberto de Oliveira et al., Quercetin and the mitochondria: A mechanistic view, Biotechnol Adv.  2016 Sep-Oct;34(5):532-549