Actions of I-3-C
Indole-3-Carbinol is an excellent anti-cancer element and has other beneficial effects on the body. It can be administered either to people predisposed to cancer or during treatments for cancer.
Recent studies indicate the strong synergistic action of the association of Idole-3-Carbinol with DIM (3,3′-Di-indolymethane).
Indole is also capable of stimulating antitumor genes p21 , p27 and p53 with preventive effect in all types of cancer as well as against Herpex Simplex virus and Human Papilloma Virus. Inhibits growth and produce apoptosis (programmed death) of cancer cells in breast cancer, cervical cancer, endometrium, prostate, colon, skin and leukemia as well as in other forms of cancers.
The doctor biologist Hien T. Lee of Berkeley University in California, found that I-3-C (Indole-3-Carbinol) is effective in the treatment of prostate cancer by blocking male hormones that are responsible for the facilitation of the multiplication of cancer cells at the level of prostate.
Until recently, studies on the anti carcinogenic effects of I-3-C had been made especially in animals or in vitro.
Indole-3-Carbinol induces a G1 phase to stop the cycle of the growth and reproduction of human malignant cells. This is significant in preventing and treating cancer because G1 growth phase occurs early in the life cycle of malignant cell. The G1 phase is dominated by the synthesis of various enzymes that are necessary for the next stage (S-phase) including also those enzymes necessary for the replication of DNA (modified DNA,”malignant”). This fact is of vital importance because it that differentiates a healthy cell to a carcinogen is precisely the modification of the DNA .
Until recently, it was known that Indole-3-Carbinol attacks Herpex Simplex and Human Papilloma (HPV) viruses. Recently, Italian researchers discovered that Indole-3-Carbinol can also attack influenza viruses, preventing viral multiplication.
Recommended way of use (for adults): 1 capsule 1-2 times a day or as directed by your health care practicioner.
Bradlow, Effects of dietary indole-3-carbinol on estrogen metabolism and spontaneous mammary tumors in mice. Carcinogenesis 12: 1571–1574
Bell, M. C., Crowley-Nowick, P., Bradlow, H. L., Sepkovic, D. W., Schmidt-Grimminger, D., Howell, P., Mayeaux, E. J., Tucker, A., Turbat-Herrera, E. A. & Mathis, J. M. (2000) Placebo-controlled trial of indole-3-carbinol in the treatment of Gynecol. Oncol, Sepkovic, D. W. & Auborn, K. (1998) Estrogen metabolism and the malignantpotential of human papillomavirus immortalized keratinocytes.