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Depression – A Neuroinflammatory Disorder

Depression – A Neuroinflammatory Disorder

Depression is now rampant in western countries. About 1 in 4 adults in the U.S. (more than 26% of the population) suffer from a diagnosable mental disorder for which powerful drugs are prescribed. That is about 30 million people on psychiatric drugs. Pharmaceutical drugs treat symptoms and may come with side effects.

Depression is now the leading cause of disability worldwide.

People with chronic depression often have significant biochemical imbalances in their neurological system.

New research has indicated that this biochemical imbalance is not genetic, but instead is due to heavy toxicity and/or severe nutritional and lifestyle deficiencies; they cause massive brain inflammation, disrupting normal neurological processes. However, overcoming chemical imbalances can be assisted naturally.

Chronic inflammation leads to slow brain processing speed, poor memory, foggy thinking. There is a brain – gut connection in the body.

Gut inflammation is caused by intestinal permeability and is related to infections and food sensitivity.

Microbiome and Depression

Microbiome and Depression: tremendous research showed the connection between gut microbiome and neurological health. Research has also indicated that low levels of healthy Lactobacillus bacteria and Bifidobacteria are linked with increased brain excitability and neurological inflammation. Low levels of neurotransmitter GABA production are associated with anxiety, seizures, depression.

Natural anti-inflammatories include exercise, sun exposure, omega-3 fatty acids, curcumin, resveratrol and adaptogen herbs (ashwagandha).

Blood sugar and Depression

Too much sugar in the blood leads to nutrient deficiencies, increasing brain oxidative stress and inflammation and inducing states of anxiety and depression.

Excessive sleepiness and insomnia disrupt circadian rhythms (sleep troubles, depression, low energy / fatigue, mood disorders, anxiety).

Gluten and brain inflammation

Gluten is a sticky storage protein that binds to the small intestinal wall where it often causes digestive and immune system disorders. Gluten is also a significant trigger in psychiatric disorders such as anxiety, bipolar disorder and depression.

Anti-Inflammatory nutrition

Low in carbohydrates, and rich in healthy fats and antioxidants – a critical factor to preventing and treating major depressive disorder.

The brain is primarily water, fat and cholesterol.

Stimulating neurogenesis

Ability of the brain to generate new healthier and stronger cells and synaptic junctions.  The brain can literally re-wire itself. In the case of depression, the brain is undergoing extreme damage from inflammation. This is happening much faster than the body can recover. That is why depression is classified as a neuroinflammatory disorder.

Anti-inflammatory diet, natural anti-inflammatory and ketosis may help. Giving thanks also helps with a positive mood, more energy and optimism.

Provita Nutrition offers a wide range of advanced natural therapeutic solutions for Brain health, Cognition & Memory, Neurological function, Pain & Inflammation. Our natural health products are made in Canada. They are high quality, unique formulations.

From these, we recommend:

Non-Synthetic GABA with P5P – 60 capsules

  • Very good products, helping you to relax.
  • Helps in the growth of the muscles.
  • Improves cognitive function in older people.
  • Recommended for stress, anxiety, nervousness, panic, epilepsy, Alzheimer.

Ashwagandha with magnesium – 60 capsules

  • Adaptogen, calming, relaxing, revitalizing tonic.
  • Contains medicinal compounds, useful from a medical point of view, such as steroidal lactones, alkaloids, colia, fatty acids, amino-acids.

NADH+ – 12,5 mg – 30 capsules

  • Nicotinamide adenine dinucleotide from Japan, 25% potency, with added CoQ10 and chlorophyll.
  • Recommended for lack of energy, fatigue, Alzheimers, Parkinson, ADHD, sports persons.
  • Physical and mental energizer.

Nervine – 60 capsules

  • Natural plants acting on the nervous level with calming, relaxing, anxiolytic effect.
  • Adaptogen, improves male fertility and female hormonal regulator.
  • Recommended for stress, anxiety, depression and insomnia.

Neuro Maximizer – 60 capsules of vegetal origin

  • A complex product for maintaining and restoring the nervous system and the brain functionality.
  • Contains 14 specific ingredients which act synergistically on the brain and the nervous system.
  • A bio-available Canadian product of pharmaceutical quality.
  • Accepted for vegetarians and vegans.
  • Certificated by Good Manufacturing Practices (GMP).

Gotu Kola – 500 mg – 120 vegetal capsules

  • Gotu Kola – the plant for longevity.
  • For memory and intelligence.
  • Recommended in cases of rheumatoid arthritis, spondylosis, psoriatic arthritis, inflammation, anxiety, venous insufficiency.
  • Certifacted by Good Manufacturing Practices (GMP).

Lion’s Mane 5000TM – 500 mg – 90 vegetable capsules

  • Lion’s Mane – 10:1 concentrated extract – equivalent to 5000 mg.
  • Lion’s Mane (Hericium erinaceus) is a mushroom with neuroprotective, nootropic, immune and antioxidant effects.

Konig PS 100+ – 60 veggie capsules

  • Phosphatidylserine + Acetylcarnitine 100 + 100 mg.
  • Dietary supplement, standardized complex of essential phospholipids + acetilcarnitine.
  • Recommended to Alzheimer’s patients (dementia, senile dementia), persons with cognitive, memory, and learning deficiencies.

Serra Plus – serrapeptase forte – 30 gastro-resistant capsules

  • Dietary supplement, super proteolytic enzyme.
  • Anti-inflammatory, anti-cystic, anti-fibrinolitic.
  • Eliminates inflammation, arthritic pain, sinus infections, digests proteins, cleans the circulatory system, dissolves fibrin (protein buildup that causes thrombosis), blood clots, dead tissue, relieves joint pains.
  • It attacks and dissolves dead matter such as dead cells from the body, fibroids, cysts, fat deposits, postoperative inflammation (trauma).

Bio-Active Acidophilus – 60 / 100 capsules

  • Contains six types of probiotic strains, with 6 billion probiotic units.
  • With addition of pectin, F.O.S. and Inulin (pre-biotics).
  • Thermally stabilized (no refrigeration required).
  • Restores the bacterial flora and help strengthen the immune system.

Sources for this article include

  • Rao TSS, Asha MR, Ramesh BN, Rao KSJ. Understanding nutrition, depression and mental illnesses. Indian Journal of Psychiatry. 2008;50(2):77-82
  • Science Direct: Inflammatory Dietary Pattern and Risk of Depression Among Women Link Here
  • Lee CH, Giuliani F. The Role of Inflammation in Depression and Fatigue. Front Immunol. 2019;10:1696. Published 2019 Jul 19. PMCID: 6658985
  • Hurley LL, Akinfiresoye L, Kalejaiye O, Tizabi Y. Antidepressant effects of resveratrol in an animal model of depression. Behav Brain Res. 2014;268:1-7. PMID: 24717328
  • Dash S, Clarke G, Berk M, Jacka FN. The gut microbiome and diet in psychiatry: focus on depression. Curr Opin Psychiatry. 2015;28(1):1-6. PMID: 25415497
  • Patel JP, Frey BN. Disruption in the Blood-Brain Barrier: The Missing Link between Brain and Body Inflammation in Bipolar Disorder?. Neural Plast. 2015;2015:708306. PMCID: 4444594
  • Peters SL, Biesiekierski JR, Yelland GW, Muir JG, Gibson PR. Randomised clinical trial: gluten may cause depression in subjects with non-coeliac gluten sensitivity – an exploratory clinical study. Aliment Pharmacol Ther. 2014;39(10):1104-1112. PMID: 24689456
  • Bottiglieri T. Folate, vitamin B12, and neuropsychiatric disorders. Nutr Rev. 1996;54(12):382-390. PMID: 9155210
  • Brain-Derived Neurotrophic Factor Stimulates Energy Metabolism in Developing Cortical Neurons. The Journal of Neuroscience. 2003 Sep; 23(23):8212– 8220. Link Here
  • Huang R, Wang K, Hu J. Effect of Probiotics on Depression: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients. 2016;8(8):483. Published 2016 Aug PMCID: 4997396
  • Dr.Jockers.com

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